Although they have several important limitations primary human hepatocytes still represent
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …

Better prediction of safety risk and understanding of mechanism of action of drug candidates
remain a major challenge in order to prevent late stage attrition. Continuous efforts are …

Current developments in the technological fields of liver tissue engineering, bioengineering,
biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent …

Over the recent years, various materials have been introduced as potential 3D cell culture
scaffolds. These include protein extracts, peptide amphiphiles, and synthetic polymers. …

We present three-dimensional (3D) in vivo images of human breast cancer based on
fluorescence diffuse optical tomography (FDOT). To our knowledge, this work represents the first …

We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional
in vivo imaging of human breast tumor based on large optical data sets. …

Hepatic tumors, exhibiting mature hepatocytes and undifferentiated cells merging with
cholangiocyte and hepatocyte phenotypes, are frequently described. The mechanisms by which …

We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical
properties for diffuse optical tomography. We have previously shown that the method gives …

Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts
during embryonic development. In this study we investigated the potential of human …

We derive conditions for the unique and simultaneous recovery of chromophore concentrations
and scattering coefficients in multispectral continuous-wave diffuse optical tomography. …