The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics
A Guillouzo, A Corlu, C Aninat, D Glaise, F Morel… - Chemico-biological …, 2007 - Elsevier
Although they have several important limitations primary human hepatocytes still represent
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …
the in vitro gold standard model for xenobiotic metabolism and toxicity studies. The large use …
Stem cell-derived hepatocytes and their use in toxicology
C Guguen-Guillouzo, A Corlu, A Guillouzo - Toxicology, 2010 - Elsevier
Better prediction of safety risk and understanding of mechanism of action of drug candidates
remain a major challenge in order to prevent late stage attrition. Continuous efforts are …
remain a major challenge in order to prevent late stage attrition. Continuous efforts are …
Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity
Current developments in the technological fields of liver tissue engineering, bioengineering,
biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent …
biomechanics, microfabrication and microfluidics have lead to highly complex and pertinent …
[HTML][HTML] Nanofibrillar cellulose hydrogel promotes three-dimensional liver cell culture
…, SW Kuisma, L Kanninen, M Lille, A Corlu… - Journal of controlled …, 2012 - Elsevier
Over the recent years, various materials have been introduced as potential 3D cell culture
scaffolds. These include protein extracts, peptide amphiphiles, and synthetic polymers. …
scaffolds. These include protein extracts, peptide amphiphiles, and synthetic polymers. …
Three-dimensional in vivo fluorescence diffuse optical tomography of breast cancer in humans
A Corlu, R Choe, T Durduran, MA Rosen… - Optics express, 2007 - opg.optica.org
We present three-dimensional (3D) in vivo images of human breast cancer based on
fluorescence diffuse optical tomography (FDOT). To our knowledge, this work represents the first …
fluorescence diffuse optical tomography (FDOT). To our knowledge, this work represents the first …
Differentiation of benign and malignant breast tumors by in-vivo three-dimensional parallel-plate diffuse optical tomography
We have developed a novel parallel-plate diffuse optical tomography (DOT) system for three-dimensional
in vivo imaging of human breast tumor based on large optical data sets. …
in vivo imaging of human breast tumor based on large optical data sets. …
[PDF][PDF] Transdifferentiation of hepatocyte‐like cells from the human hepatoma HepaRG cell line through bipotent progenitor
…, D Kremsdorf, C Guguen‐Guillouzo, A Corlu - …, 2007 - Wiley Online Library
Hepatic tumors, exhibiting mature hepatocytes and undifferentiated cells merging with
cholangiocyte and hepatocyte phenotypes, are frequently described. The mechanisms by which …
cholangiocyte and hepatocyte phenotypes, are frequently described. The mechanisms by which …
Diffuse optical tomography with spectral constraints and wavelength optimization
We present an algorithm that explicitly utilizes the wavelength dependence of tissue optical
properties for diffuse optical tomography. We have previously shown that the method gives …
properties for diffuse optical tomography. We have previously shown that the method gives …
[PDF][PDF] Generation of functional cholangiocyte‐like cells from human pluripotent stem cells and HepaRG cells
…, A Raveux, L Combettes, A Weber, A Corlu… - …, 2014 - Wiley Online Library
Cholangiocytes are biliary epithelial cells, which, like hepatocytes, originate from hepatoblasts
during embryonic development. In this study we investigated the potential of human …
during embryonic development. In this study we investigated the potential of human …
Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography
We derive conditions for the unique and simultaneous recovery of chromophore concentrations
and scattering coefficients in multispectral continuous-wave diffuse optical tomography. …
and scattering coefficients in multispectral continuous-wave diffuse optical tomography. …