To a certain extent, all cellular, physiological, and pathological phenomena that occur in
cells are accompanied by ionic changes. The development of techniques allowing the …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

The gut microbiota produce hundreds of bioactive compounds, including B‐vitamins, which
play significant physiological roles in hosts by supporting the fitness of symbiotic species and …

It is a golden age for animal movement studies and so an opportune time to assess priorities
for future work. We assembled 40 experts to identify key questions in this field, focussing on …

There have been efforts around the globe to track individuals of many marine species and
assess their movements and distribution, with the putative goal of supporting their …

Background Atrial fibrillation, the most common sustained cardiac arrhythmia and a major
cause of stroke, results from simultaneous reentrant wavelets. Its spontaneous initiation has …

Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …

Individuals with rheumatoid arthritis frequently have autoantibodies to citrullinated peptides,
suggesting the involvement of the peptidylarginine deiminases citrullinating enzymes (…

We conducted a genome-wide association study using 207,097 SNP markers in Japanese
individuals with type 2 diabetes and unrelated controls, and identified KCNQ1 (potassium …

Background—The end point for catheter ablation of pulmonary vein (PV) foci initiating atrial
fibrillation (AF) has not been determined. Methods and Results—Ninety patients underwent …