Structure and dynamics of the yeast SWR1-nucleosome complex
INTRODUCTION Canonical nucleosomes contain two copies of each of four histone proteins:
H2A, H2B, H3, and H4. However, variants of these histones can be inserted by adenosine …
H2A, H2B, H3, and H4. However, variants of these histones can be inserted by adenosine …
[HTML][HTML] Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human …
JP Tsai, CH Lee, TH Ying, CL Lin, CL Lin, JT Hsueh… - Oncotarget, 2015 - ncbi.nlm.nih.gov
The use of dietary bioactive compounds in chemoprevention can potentially reverse, suppress,
or even prevent cancer progression. However, the effects of licochalcone A (LicA) on …
or even prevent cancer progression. However, the effects of licochalcone A (LicA) on …
[HTML][HTML] Protodioscin induces apoptosis through ROS-mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer cells
CL Lin, CH Lee, CM Chen, CW Cheng… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Protodioscin (PD) is a steroidal saponin with anti-cancer effects on a
number of cancer cells, but the anti-tumor effects and mechanism of action of PD on human …
number of cancer cells, but the anti-tumor effects and mechanism of action of PD on human …
Diverse nucleosome site-selectivity among histone deacetylase complexes
Histone acetylation regulates chromatin structure and gene expression and is removed by
histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to …
histone deacetylases (HDACs). HDACs are commonly found in various protein complexes to …
[HTML][HTML] Inhibition of eIF2α dephosphorylation accelerates pterostilbene-induced cell death in human hepatocellular carcinoma cells in an ER stress and autophagy …
CL Yu, SF Yang, TW Hung, CL Lin, YH Hsieh… - Cell Death & …, 2019 - nature.com
Hepatocellular carcinoma (HCC) is the one of the most common cancers worldwide. Because
the side effects of current treatments are severe, new effective therapeutic strategies are …
the side effects of current treatments are severe, new effective therapeutic strategies are …
Synergistic effect of fisetin combined with sorafenib in human cervical cancer HeLa cells through activation of death receptor-5 mediated caspase-8/caspase-3 and the …
MT Lin, CL Lin, TY Lin, CW Cheng, SF Yang, CL Lin… - Tumor Biology, 2016 - Springer
Combining antitumor agents with bioactive compounds is a potential strategy for improving
the effect of chemotherapy on cancer cells. The goal of this study was to elucidate the …
the effect of chemotherapy on cancer cells. The goal of this study was to elucidate the …
Hibiscus sabdariffa leaf polyphenolic extract inhibits LDL oxidation and foam cell formation involving up-regulation of LXRα/ABCA1 pathway
JH Chen, CJ Wang, CP Wang, JY Sheu, CL Lin, HH Lin - Food chemistry, 2013 - Elsevier
The oxidative modification of low-density lipoprotein (LDL) is involved in the pathogenesis
of atherosclerotic lesions through the formation of macrophage-derived foam cells. In the …
of atherosclerotic lesions through the formation of macrophage-derived foam cells. In the …
Praeruptorin A reduces metastasis of human hepatocellular carcinoma cells by targeting ERK/MMP1 signaling pathway
Praeruptorin A (PA) is one of the active ingredients found in the dried root of Peucedanum
praeruptorum Dunn, has been reported to possess anticancer effects against various types of …
praeruptorum Dunn, has been reported to possess anticancer effects against various types of …
β‐mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP‐2 and MMP‐9 expression and activating the ERK and JNK …
…, YH Teng, FJ Lu, WH Hsu, CL Lin… - Environmental …, 2017 - Wiley Online Library
β‐mangostin is a dietary xanthone that has been reported to have the anticancer properties
in some human cancer cell types. However, the antimetastatic effect and molecular …
in some human cancer cell types. However, the antimetastatic effect and molecular …
Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
CL Lin, YT Wang, WZ Yang, YY Hsiao… - Nucleic acids …, 2012 - academic.oup.com
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease that
degrades specific mRNA and miRNA, and imports RNA into mitochondria, and thus regulates …
degrades specific mRNA and miRNA, and imports RNA into mitochondria, and thus regulates …