Tumour-infiltrating lymphocytes are associated with a survival benefit in several tumour
types and with the response to immunotherapy 1 , 2 , 3 , 4 , 5 , 6 , 7 – 8 . However, the reason …

The differentiation of human memory CD8 T cells is not well understood. Here we address
this issue using the live yellow fever virus (YFV) vaccine, which induces long-term immunity in …

Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic
choriomeningitis virus infection 1 . Here we examine the underlying basis for this synergy…

This paper employs a simple stochastic model to investigate how transaction cost and strategic
option considerations interact to influence a firm's evaluation of collaborative venturing …

This paper summarizes work on the mode of inheritance of resistance to root-knot in tomatoes.
Tests have confirmed the hypothesis that the inheritance of resistance to severe galling …

The phenomenal success of the film, and 2000 Oscar Best Picture winner, Gladiator ensures
that ancient Rome will continue to inspire moviemakers and attract audiences as it has …

CD5 activates casein kinase 2 (CK2), a serine/threonine kinase that constitutively
associates with the CK2-binding domain at the end of its cytoplasmic tail. To determine the …

Purpose: Combination of chemotherapy with programmed cell death 1 (PD-1) blockade is a
front-line treatment for lung cancer. However, it remains unknown whether and how …

In response to viral infection, CD8 + T cells undergo expansion and differentiate into distinct
classes of effector cells. After clearance of the virus, a small population of long-lived memory …

Inhibitors of glycogen synthase kinase 3 (GSK3) are being explored as therapy for chronic
inflammatory diseases. We previously demonstrated that the GSK inhibitor lithium is beneficial …