A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL)
disease tumor suppressor gene. A restriction fragment encompassing the gene showed …

Tough hydrogels, polymeric network structures with excellent mechanical properties (such
as high stretchability and toughness), are emerging soft materials. Despite their remarkably …

Von Hippel‐Lindau disease (VHL) is an inherited neoplastic disease characterized by a
predisposition to develop retinal angiomas, central nervous system hemangioblastomas, renal …

Select members of the Wnt family of secreted glycoproteins have been implicated in inducing
the myogenic determinant genes Pax3, MyoD and Myf5 during mammalian embryogenesis …

Strange fits of passion I have known… (W Wordsworth, ‘Strange fits of passion’.) bHLH–PAS
proteins are regulators of developmental and physiological events that are well conserved …

Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited
kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal …

Skeletal muscle tissue provides mechanical force for locomotion of all vertebrate animals. It
is prone to damage from acute physical trauma and physiological stress. To cope with this, it …

Embryonic patterning in vertebrates is dependent upon the balance of inductive signals and
their specific antagonists. We show thatNoggin, which encodes a bone morphogenetic …

Background: Among women who practice breast self-examination (BSE), breast cancers may
be detected when they are at an earlier stage and are smaller than in women who do not …

An early step in the development of vertebrae, ribs, muscle, and dermis is the differentiation
of the somitic mesoderm into dermomyotome dorsally and sclerotome ventrally. To analyze …