… Since the 1995 β-lactamase compilation (16), at least 9 TEM and 29 SHV 2b enzymes have
been described (G. Jacoby and K. Bush, http://www.lahey.org/Studies/ ) often in the course …

A classification scheme for-lactamases based on functional characteristics is presented.
Three major groups of enzymes are defined by their substrate and inhibitor profiles: group 1 …

AmpC β-lactamases are clinically important cephalosporinases encoded on the chromosomes
of many of the Enterobacteriaceae and a few other organisms, where they mediate …

A compilation of paleoclimate records from lake sediments, trees, glaciers, and marine sediments
provides a view of circum-Arctic environmental variability over the last 400 years. From …

… George Jacoby was responsible for strain construction, plasmid characterisation, β-lactamase
assays, and mutation studies in Bedford, Massachusetts, USA. He wrote the article with …

The predominant mechanism for resistance to-lactam antibiotics in gram-negative bacteria is
the synthesis of-lactamase. To meet this challenge,-lactams with greater-lactamase stability…

The β-lactamases are the major bacterial defense of gram-negative bacteria against β-lactam
antibiotics. This review details the many types of β-lactamases, explains how they can be …

… We removed cell debris by centrifugation at 15,000g for 15 min at 4 C, and the supernatant
constituted the cell extract. For this process, 150 ml of culture yielded 4 ml of extract. We …

Fluoroquinolone resistance is emerging in Gram-negative pathogens worldwide. The
traditional understanding that quinolone resistance is acquired only through mutation and …

Table 1 lists the extended-spectrum,-lactamases related to TEM-1, TEM-2, or TEM-13, a
variant identical to TEM-2 in isoelectric point (pl) and resistance phenotype (44). The 16 …