Worldwide human relationships inferred from genome-wide patterns of variation
Human genetic diversity is shaped by both demographic and biological factors and has
fundamental implications for understanding the genetic basis of diseases. We studied 938 …
fundamental implications for understanding the genetic basis of diseases. We studied 938 …
[HTML][HTML] Personal omics profiling reveals dynamic molecular and medical phenotypes
Personalized medicine is expected to benefit from combining genomic information with regular
monitoring of physiological states by multiple high-throughput methods. Here, we present …
monitoring of physiological states by multiple high-throughput methods. Here, we present …
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human
…, X Kong, L Du, P Hao, H Tang… - Proceedings of the …, 2005 - National Acad Sciences
The genomic sequences of severe acute respiratory syndrome coronaviruses from human
and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly …
and palm civet of the 2003/2004 outbreak in the city of Guangzhou, China, were nearly …
[PDF][PDF] The importance of race and ethnic background in biomedical research and clinical practice
A debate has recently arisen over the use of racial classification in medicine and biomedical
research. In particular, with the completion of a rough draft of the human genome, some …
research. In particular, with the completion of a rough draft of the human genome, some …
Programming the magnitude and persistence of antibody responses with innate immunity
…, I Skountzou, RA Albrecht, D Koutsonanos, T Hua… - Nature, 2011 - nature.com
Many successful vaccines induce persistent antibody responses that can last a lifetime. The
mechanisms by which they do so remain unclear, but emerging evidence indicates that they …
mechanisms by which they do so remain unclear, but emerging evidence indicates that they …
[HTML][HTML] Categorization of humans in biomedical research: genes, race and disease
A debate has arisen regarding the validity of racial/ethnic categories for biomedical and
genetic research. Some claim 'no biological basis for race' while others advocate a 'race-neutral' …
genetic research. Some claim 'no biological basis for race' while others advocate a 'race-neutral' …
[HTML][HTML] Predicting diabetes mellitus with machine learning techniques
Diabetes mellitus is a chronic disease characterized by hyperglycemia. It may cause many
complications. According to the growing morbidity in recent years, in 2040, the world’s …
complications. According to the growing morbidity in recent years, in 2040, the world’s …
Estimation of individual admixture: analytical and study design considerations
The genome of an admixed individual represents a mixture of alleles from different ancestries.
In the United States, the two largest minority groups, African‐Americans and Hispanics, …
In the United States, the two largest minority groups, African‐Americans and Hispanics, …
[PDF][PDF] Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
H Tang, T Quertermous, B Rodriguez… - The American Journal of …, 2005 - cell.com
We have analyzed genetic data for 326 microsatellite markers that were typed uniformly in a
large multiethnic population-based sample of individuals as part of a study of the genetics of …
large multiethnic population-based sample of individuals as part of a study of the genetics of …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
…, JA Lynch, SM Damrauer, PWF Wilson, H Tang… - Nature medicine, 2022 - nature.com
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …