User profiles for John Rumsey

John W. Rumsey, Ph.D.

Javelin Biotech, Inc.
Verified email at javelinbio.com
Cited by 1779

Conducting event studies with thinly traded stocks

E Maynes, J Rumsey - Journal of Banking & Finance, 1993 - Elsevier
Procedures for measuring abnormal performance around events when securities do not
trade daily are examined. A rank test patterned after the statistic proposed by Corrado [Corrado, …

[PDF][PDF] Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity

…, L Lai, JF Zechner, T Geng, Z Yan, JW Rumsey… - Cell metabolism, 2010 - cell.com
Evidence is emerging that the PGC-1 coactivators serve a critical role in skeletal muscle
metabolism, function, and disease. Mice with total PGC-1 deficiency in skeletal muscle (PGC-1α …

[HTML][HTML] Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

Z Gan, J Rumsey, BC Hazen, L Lai… - The Journal of …, 2013 - Am Soc Clin Investig
The mechanisms involved in the coordinate regulation of the metabolic and structural programs
controlling muscle fitness and endurance are unknown. Recently, the nuclear receptor …

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

…, T Sasserath, LR Bridges, JW Rumsey… - Science translational …, 2019 - science.org
A pumpless, reconfigurable, multi-organ–on–a–chip system containing recirculating serum-free
medium can be used to predict preclinical on-target efficacy, metabolic conversion, and …

A defined long-term in vitro tissue engineered model of neuromuscular junctions

M Das, JW Rumsey, N Bhargava, M Stancescu… - Biomaterials, 2010 - Elsevier
Neuromuscular junction (NMJ) formation, occurring between motoneurons and skeletal muscle,
is a complex multistep process involving a variety of signaling molecules and pathways. …

Neuromuscular junction formation between human stem-cell-derived motoneurons and rat skeletal muscle in a defined system

X Guo, M Das, J Rumsey, M Gonzalez… - … Engineering Part C …, 2010 - liebertpub.com
To date, the coculture of motoneurons (MNs) and skeletal muscle in a defined in vitro system
has only been described in one study and that was between rat MNs and rat skeletal muscle…

Differential monocyte actuation in a three‐organ functional innate immune system‐on‐a‐chip

T Sasserath, JW Rumsey, CW McAleer… - Advanced …, 2020 - Wiley Online Library
A functional, human, multiorgan, pumpless, immune system‐on‐a‐chip featuring
recirculating THP‐1 immune cells with cardiomyocytes, skeletal muscle, and liver in separate …

[HTML][HTML] Validation of an adipose-liver human-on-a-chip model of NAFLD for preclinical therapeutic efficacy evaluation

VL Slaughter, JW Rumsey, R Boone, D Malik, Y Cai… - Scientific Reports, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly
correlates with the growing incidence of obesity and type II diabetes. We have developed a …

Photolithographic patterning of C2C12 myotubes using vitronectin as growth substrate in serum‐free medium

…, W Wang, A Natarajan, JW Rumsey… - Biotechnology …, 2007 - Wiley Online Library
The C2C12 cell line is frequently used as a model of skeletal muscle differentiation. In our
serum‐free defined culture system, differentiation of C2C12 cells into myotubes required …

[PDF][PDF] A functional hiPSC-cortical neuron differentiation and maturation model and its application to neurological disorders

K Autar, X Guo, JW Rumsey, CJ Long, N Akanda… - Stem Cell Reports, 2022 - cell.com
The maturation and functional characteristics of human induced pluripotent stem cell (hiPSC)-cortical
neurons has not been fully documented. This study developed a phenotypic model …