Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
The translocator protein (18 kDa) (TSPO) is localized primarily in the outer mitochondrial
membrane of steroid-synthesizing cells, including those in the central and peripheral nervous …
membrane of steroid-synthesizing cells, including those in the central and peripheral nervous …
Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors
M Schumacher, C Mattern, A Ghoumari… - Progress in …, 2014 - Elsevier
Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …
Progesterone: therapeutic opportunities for neuroprotection and myelin repair
M Schumacher, R Guennoun, DG Stein… - Pharmacology & …, 2007 - Elsevier
Progesterone and its metabolites promote the viability of neurons in the brain and spinal cord.
Their neuroprotective effects have been documented in different lesion models, including …
Their neuroprotective effects have been documented in different lesion models, including …
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
…, EM Catá, CM Crawford, KL Sinagoga, M Schumacher… - Nature, 2014 - nature.com
Gastric diseases, including peptic ulcer disease and gastric cancer, affect 10% of the world’s
population and are largely due to chronic Helicobacter pylori infection 1 , 2 , 3 . Species …
population and are largely due to chronic Helicobacter pylori infection 1 , 2 , 3 . Species …
[HTML][HTML] Secure and trustable electronic medical records sharing using blockchain
…, Z Xu, S Ryu, M Schumacher… - AMIA annual …, 2017 - ncbi.nlm.nih.gov
Electronic medical records (EMRs) are critical, highly sensitive private information in
healthcare, and need to be frequently shared among peers. Blockchain provides a shared, …
healthcare, and need to be frequently shared among peers. Blockchain provides a shared, …
Progesterone synthesis and myelin formation by Schwann cells
HL Koenig, M Schumacher, B Ferzaz, AND Thi… - Science, 1995 - science.org
Progesterone is shown here to be produced from pregnenolone by Schwann cells in peripheral
nerves. After cryolesion of the sciatic nerve in male mice, axons regenerate and become …
nerves. After cryolesion of the sciatic nerve in male mice, axons regenerate and become …
Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes.
DT Harris, MJ Schumacher… - Proceedings of the …, 1992 - National Acad Sciences
Successful implementation of bone marrow transplantation for hematopoietic reconstitution
is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-…
is limited by the lack of suitably HLA-matched donors and by the occurrence of graft-versus-…
Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects
…, D Tuerck, A Floesser, B Kiese, M Schumacher… - Science, 2009 - science.org
Most antianxiety drugs (anxiolytics) work by modulating neurotransmitters in the brain.
Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is limited by …
Benzodiazepines are fast and effective anxiolytic drugs; however, their long-term use is limited by …
Neurosteroid quantification in human brain regions: comparison between Alzheimer's and nondemented patients
…, B Eychenne, A Pianos, M Schumacher… - The Journal of …, 2002 - academic.oup.com
Some neurosteroids have been shown to display beneficial effects on neuroprotection in
rodents. To investigate the physiopathological significance of neurosteroids in Alzheimer’s …
rodents. To investigate the physiopathological significance of neurosteroids in Alzheimer’s …
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
…, M Schumacher, EM Steidl, D Maux, M Delaage… - … of Pharmacology and …, 2007 - ASPET
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
progressive death of cortical and spinal motor neurons, for which there is no effective …
progressive death of cortical and spinal motor neurons, for which there is no effective …