… To place these results in the context of the drift-barrier hypothesis, it is necessary to go
beyond the per-site base-substitution mutation rate, u, as selection operates on the genome-wide …

… These polymerases temporarily take the place of the replicative polymerase (Pol III) and
synthesize past blocking lesions in the DNA template. One of the SOS polymerases is Pol II, a …

When properly determined, spontaneous mutation rates are a more accurate and biologically
meaningful reflection of underlying mutagenic mechanisms than are mutant frequencies. …

Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding
evolutionary and molecular processes. In this report, we analyze spontaneous mutations …

Mutation rates are generally thought not to be influenced by selective forces. This doctrine
rests on the results of certain classical studies of the mutations that make bacteria resistant to …

… Foster,2 Peter Brooks,3,4 and Richard Fishel1,* 1 Genetics and … These observations place
the rate of MutL-dependent removal … These data place significant restrictions on MMR models. …

Spontaneous mutations arise as a result of cellular processes that act upon or damage DNA.
Accurate determination of spontaneous mutation rates can contribute to our understanding …

We have determined the base substitutions generated by metabolically activated aflatoxin
B1 in the lacI gene of a uvrB- strain of Escherichia coli. By monitoring over 70 different …

… Ohmori, and PL Foster unpubl. data). The cellular levels of Pol IV are elevated three- to …
Ohmori, and PL Foster unpubl. data). We assume that this increase in Pol IV is due to the partial …

… interaction between GroE and Pol IV; suggesting that GroE is required for the stability or
activity of some other positive effector Pol IV (JC Layton, PL Foster, Submitted for publication). …