… The first chapter (RA Young) presents a general introductory account of what the Rietveld
method is and how it works. In the second chapter, HM Rietveld reports on the inception and …

The transcription factors OCT4, SOX2, and NANOG have essential roles in early development
and are required for the propagation of undifferentiated embryonic stem (ES) cells in …

… We also thank members of the Gifford, Young and Jaenisch laboratories for discussions
and critical review of the manuscript. We are grateful to T. Magnuson for the Eed mutant (17Rn5-…

The gene expression programs that establish and maintain specific cell states in humans
are controlled by thousands of transcription factors, cofactors, and chromatin regulators. …

Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes
that define cell identity. Improved understanding of the roles that super-enhancers play in …

Developmental programs are controlled by transcription factors and chromatin regulators,
which maintain specific gene expression programs through epigenetic modification of the …

We have determined how most of the transcriptional regulators encoded in the eukaryote
Saccharomyces cerevisiaeassociate with genes across the genome in living cells. Just as …

Recruitment of the RNA polymerase II (Pol II) transcription initiation apparatus to promoters
by specific DNA-binding transcription factors is well recognized as a key regulatory step in …